Rapid disruption of epithelial barrier function by Salmonella typhimurium is associated with structural modification of intercellular junctions.
نویسندگان
چکیده
Short-term infection of MDCK II monolayers with Salmonella typhimurium SL1344 caused a progressive decrease in transepithelial electrical resistance concomitant with decreased cation permselectivity and increased paracellular inulin flux. Cytochemical staining of F-actin, E-cadherin, and ZO-1 revealed the concentration of each junctional protein in invaded cells as a result of contraction at their apical poles and resultant distortion of adjacent uninvaded cells.
منابع مشابه
Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage.
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عنوان ژورنال:
- Infection and immunity
دوره 63 1 شماره
صفحات -
تاریخ انتشار 1995